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ESOTRAC
ESOTRAC - listening to light

ESOTRAC

listening to light

ESOTRAC - addressing an urgent medical need

ESOTRAC

addressing an urgent medical need

ESOTRAC - challenging endeavor

ESOTRAC

challenging endeavor

ESOTRAC - increasing penetration depth & adaptation of software

ESOTRAC

increasing penetration depth & adaptation of software

ESOTRAC - offering multispectral analysis

ESOTRAC

offering multispectral analysis

ESOTRAC - international interdisciplinary team

ESOTRAC

international interdisciplinary team

About ESOTRAC

ESOTRAC logo
ESOTRAC logo

 

ESOTRAC, a 4-year research program bringing together engineers and physicians, aims to significantly improve the detection of early-stage esophageal cancer. The interdisciplinary, 5-country research team will develop an innovative endoscope that combines sensing of pathophysiological tissue signatures resolved by multi-spectral optoacoustic (photoacoustic) tomography (MSOT) with morphological disease signatures provided by optical coherence tomography (OCT).

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Overview

 

More than 450.000 people are diagnosed with esophageal cancer (EC) each year worldwide and ~400.000 die annually from the disease. The high mortality rate is attributed to the late detection of the disease, largely due to insufficient detection methods today. Besides loss of life, treating late disease incurs costs in the range of $80,000-250,000 per patient lifetime making esophageal cancer among the most expensive diseases to treat in oncology today. Risk factors, including obesity, chronic gastroesophageal reflux disease (GERD) and Barret’s esophagus, implicate diagnostically a much larger population. It is estimated that at least 100 million people suffer of GERD in Western Countries and that ~10 million people in Western countries live with Barrett’s esophagus. Alarmingly, due to an aging and more overweight population the incidence rates of GERD, Barrett’s esophagus and EC are increasing.

Today, EC detection and diagnosis is typically based on white-light endoscopy (WLE), i.e. the visual inspection of the esophagus lumen through an optical system (endoscope) and subsequent pathological analysis of biopsied samples. Human vision however is insensitive to detecting early disease (dysplasia / sub-surface lesions) and lacks specificity and staging ability compromising disease prognosis. Due to WLE limitations, random biopsies may be prescribed to improve the chances of detecting early disease and tumor staging. Random tissue sampling is nevertheless sub-optimal and it may miss EC. Therefore, EC is often detected late in the course of development, which decreases the five year survival rate by more than 80% compared to early detection of the disease.

Thus, a novel tool for early detection of EC is urgently needed.

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Partners

Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt
University of Cambridge
SONAXIS
Medizinische Universität Wien
RayFos Ltd.
Ascenion GmbH
Amplitude Systèmes
Danmarks Tekniske Universitet
Statice
Fine-tuning the endoscope design for screening patients

11.07.2019

Fine-tuning the endoscope design for screening patients

During a meeting in Munich in June partners from STATICE, SONAXIS, the Medical University of Vienna, and the Helmholtz Zentrum München worked together...

Integration of OCT and MSOT at the Cambridge University Hospital

04.07.2019

Integration of OCT and MSOT at the Cambridge University Hospital

ESOTRAC partners from the University of Cambridge, the Helmholtz Zentrum München, the Medical University of Vienna, and RayFos Ltd. gathered in the...

Frontpage of Physics World Focus on Optics & Photonics

07.06.2019

Physics World Magazine features ESOTRAC

Joe McEntee wrote a great article about our approaches and goals in ESOTRAC based on an interview with Prof. Vasilis Ntziachristos which appeared in...

Dinner in Copenhagen

07.06.2019

EU projects ESOTRAC and MIB united for dinner and discussions

ESOTRAC invited members of the EU Project MIB to a joint working dinner on May 15, 2019 in Copenhagen.

Under the headline „ESOTRAC meets MIB:...

Group photo of 5th consortium meeting in Copenhagen

07.06.2019

Pushing advancements at the 5th consortium meeting in Copenhagen

On May 15, 2019 the ESOTRAC partners gathered for the 5th consortium meeting at Scandic Copenhagen, hosted by the Technical University of Denmark....

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