ESOTRAC
ESOTRAC - listening to light

ESOTRAC

listening to light

ESOTRAC - addressing an urgent medical need

ESOTRAC

addressing an urgent medical need

ESOTRAC - challenging endeavor

ESOTRAC

challenging endeavor

ESOTRAC - increasing penetration depth & adaptation of software

ESOTRAC

increasing penetration depth & adaptation of software

ESOTRAC - offering multispectral analysis

ESOTRAC

offering multispectral analysis

ESOTRAC - international interdisciplinary team

ESOTRAC

international interdisciplinary team

About ESOTRAC

ESOTRAC logo
ESOTRAC logo

 

ESOTRAC, a 4-year research program bringing together engineers and physicians, aims to significantly improve the detection of early-stage esophageal cancer. The interdisciplinary, 5-country research team will develop an innovative endoscope that combines sensing of pathophysiological tissue signatures resolved by multi-spectral optoacoustic (photoacoustic) tomography (MSOT) with morphological disease signatures provided by optical coherence tomography (OCT).

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Overview

 

More than 450.000 people are diagnosed with esophageal cancer (EC) each year worldwide and ~400.000 die annually from the disease. The high mortality rate is attributed to the late detection of the disease, largely due to insufficient detection methods today. Besides loss of life, treating late disease incurs costs in the range of $80,000-250,000 per patient lifetime making esophageal cancer among the most expensive diseases to treat in oncology today. Risk factors, including obesity, chronic gastroesophageal reflux disease (GERD) and Barret’s esophagus, implicate diagnostically a much larger population. It is estimated that at least 100 million people suffer of GERD in Western Countries and that ~10 million people in Western countries live with Barrett’s esophagus. Alarmingly, due to an aging and more overweight population the incidence rates of GERD, Barrett’s esophagus and EC are increasing.

Today, EC detection and diagnosis is typically based on white-light endoscopy (WLE), i.e. the visual inspection of the esophagus lumen through an optical system (endoscope) and subsequent pathological analysis of biopsied samples. Human vision however is insensitive to detecting early disease (dysplasia / sub-surface lesions) and lacks specificity and staging ability compromising disease prognosis. Due to WLE limitations, random biopsies may be prescribed to improve the chances of detecting early disease and tumor staging. Random tissue sampling is nevertheless sub-optimal and it may miss EC. Therefore, EC is often detected late in the course of development, which decreases the five year survival rate by more than 80% compared to early detection of the disease.

Thus, a novel tool for early detection of EC is urgently needed.

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Partners

Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt
University of Cambridge
SONAXIS
Medizinische Universität Wien
RayFos Ltd.
Ascenion GmbH
Amplitude Systèmes
Danmarks Tekniske Universitet
Statice
The cover of Journal of Biophotonics with the top downoaded paper of Dr. He

11.05.2020

Top downloaded paper for ESOTRAC

The article „Capsule optoacoustic endoscopy for esophageal imaging“ is among the top downloaded, most read articles in Journal of Biophotonics! It was...

Group portrait of 6th consortium meeting in Paris

12.02.2020

The storm could not prevent us from brainstorming

The storm Ciara — or Sabine — tore through parts of Europe, causing chaotic traffic conditions. Nevertheless, the ESOTRAC consortium found their way...

Scientists and reviewers on the second review meeting of ESOTRAC

28.11.2019

„You have done a wonderful job“

…said EC project officer Eddy Corthals at the end of our second review meeting of ESOTRAC, held on November 26th in Munich including a live demo of...

Collage of Nordic-Bavarian Partnering Workshop

08.11.2019

Nordic-Bavarian Partnering Workshop

HMGU presented ESOTRAC at the “Nordic-Bavarian Partnering Workshop: Research and Innovation for Health, Hospitals and Integrated Care” co-hosted by...

Collage of Smart Bioelectronic and Wearable Systems Workshop photos

24.10.2019

Smart Bioelectronic and Wearable Systems

ESOTRAC took part in the EC Workshop “Smart Bioelectronic and Wearable Systems“ from 22. - 23. October 2019 in Brussels. Market leaders, innovators,...